Gene specifically expressed in human fetal cardiac muscle

Details Gene specifically expressed in human fetal cardiac muscle Gene specifically expressed in human fetal cardiac muscle

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61P 9/10 (2006.01) C07K 14/425 (2006.01) C07K 14/47 (2006.01) C12P 21/02 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2380472

A DNA (cDNA) complementary to an mRNA showing different expression doses in a fetal heart and in an adult heart; a protein encoded by this DNA; a DNA in the transcriptional regulatory domain of this gene; an antibody against the above protein; a method of detecting the protein and the DNA; DNAs in the transcriptional regulatory domains of the above DNA, protein, antibody and gene; and diagnostics and remedies for various heart diseases caused by heart muscle necrosis (cardiac hypertrophy, cardiac failure, etc.) which contain a vector containing DNA of the transcriptional regulatory domain of the above- described gene, etc.

L'invention concerne un ADN (complémentaire ADNc) d'un ARNm présentant différentes doses d'expression dans un coeur foetal et dans un coeur adulte; une protéine codée par cet ADN; un ADN dans le domaine régulateur de transcription de ce gène; un anticorps contre la protéine précitée; une méthode de détection de la protéine et de l'ADN; des ADN dans les domaines régulateurs de transcription de l'ADN, la protéine, l'anticorps et le gène précité; ainsi qu'un diagnostic et des remèdes contre diverses maladies cardiaques engendrées par une nécrose du muscle cardiaque (hypertrophie cardiaque, insuffisance cardiaque, etc.) lesquels contiennent un vecteur contenant l'ADN du domaine régulateur de transcription du gène décrit ci-dessus, etc.

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