A - Human Necessities – 01 – K
Patent
A - Human Necessities
01
K
A01K 67/027 (2006.01) C07K 14/47 (2006.01) C12N 15/12 (2006.01) C12N 15/85 (2006.01) G01N 33/50 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2416381
The present invention provides a gene-targeted, non-human mammal having a gene encoding a mutant protein product of a mutated FAD presenilin-1 (PS-1) gene, a human FAD Swedish mutation, and a humanized A.beta. mutation, and generational offspring thereof and a gene-targeted, non-human mammal having a gene encoding a mutant protein product of a mutated FAD PS-1 gene and a human Swedish APP695 mutation, and generational offspring thereof, as well as methods of identifying compounds useful in treating Alzheimer's disease, and to methods of treating Alzheimer's disease.
L'invention concerne un mammifère non humain à gène cible possédant un gène codant pour un produit de protéine mutant d'un gène préséniline-1 (PS-1) de la maladie d'Alzheimer familiale (FAD) muté, une mutation suédoise de FAD humaine, et une mutation A.beta. humanisée, ainsi que la descendance de ce mammifère. L'invention concerne également un mammifère non humain à gène cible possédant un gène codant pour un produit de protéine mutant d'un gène PS-1 de FAD muté et une mutation APP695 suédoise humaine, et la descendance de ce mammifère, ainsi que des procédés d'identification de composés utiles dans le traitement de la maladie d'Alzheimer, et des méthodes de traitement de la maladie d'Alzheimer.
Dorfman Karen
Reaume Andrew G.
Scott Richard W.
Cephalon Inc.
Goudreau Gage Dubuc
LandOfFree
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