Gene that imparts selective proliferation activity

Details Gene that imparts selective proliferation activity Gene that imparts selective proliferation activity

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 31/135 (2006.01) C07K 14/47 (2006.01) C07K 14/52 (2006.01) C07K 14/705 (2006.01) C07K 14/715 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12N 15/12 (2006.01) C12N 15/19 (2006.01) C12N 15/63 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2309324

Selective amplification of cells is enabled by introducing into cells a gene encoding a fusion protein comprising (a) a mutant estrogen receptor that is unresponsive to a estrogen and that is responsive to a tamoxifen, the derivative thereof, or the metabolite thereof, and (b)_a domain that imparts proliferation activity to the cells upon the association and stimulating the cells with the ligand.

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