Gene therapeutic for cerebrovascular disorders

A - Human Necessities – 61 – K

Patent

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A61K 48/00 (2006.01) A61K 9/06 (2006.01) A61K 9/08 (2006.01) A61K 9/107 (2006.01) A61K 9/20 (2006.01) A61K 9/28 (2006.01) A61K 9/48 (2006.01) A61K 31/711 (2006.01) A61K 38/18 (2006.01) A61K 38/27 (2006.01) A61P 9/00 (2006.01) A61P 9/10 (2006.01) A61P 25/28 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2490357

It is intended to provide a novel method of treating cerebrovascular disorders which comprises overexpressing HGF by transferring an HGF gene. According to this method with the use of the HGF gene, cerebrovascular disorders such as brain infarction can be actively treated via gene transfer. Thus, it becomes possible to maintain nerve functions and inhibit infarction in a patient for whom no efficacious therapy has been established so far.

La présente invention concerne un nouveau procédé pour traiter des troubles cérébrovasculaires. On a recours à une surexpression du HGF par transfert d'un gène HGF. Selon ce procédé, grâce à l'utilisation du gène HGF, des troubles crébrovasculaires tels que l'infarctus cérébral peut se traiter de façon active par transfert génique. Il est ainsi possible de conserver des fonctions nerveuses et d'inhiber l'infarcissement chez un patient pour lequel aucune thérapie efficace n'a pu être établie jusqu'à présent.

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