Gene therapy for congestive heart failure

Details Gene therapy for congestive heart failure Gene therapy for congestive heart failure

C - Chemistry, Metallurgy

12

N

C12N 9/88 (2006.01) C12N 9/12 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2395839

The present invention relates to methods and compositions for enhancing cardiac function in mammalian hearts by inserting transgenes that increase beta-adrenergic responsiveness within the myocardium. The present invention can thus be used in the treatment of heart disease, especially congestive heart failure.

La présente invention concerne des méthodes et des compositions permettant d'améliorer la fonction cardiaque de coeurs mammaliens par insertion de transgènes qui augmentent la sensibilité bêta-adrénergique à l'intérieur du myocarde. On peut utiliser lesdites méthodes et compositions de cette invention dans le traitement de cardiopathie, notamment d'insuffisance cardiaque congestive.

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