Gene therapy for critical limb ischemia with wild type or...

A - Human Necessities – 61 – K

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Details

A61K 48/00 (2006.01) A61K 31/7088 (2006.01) A61K 38/44 (2006.01) A61P 9/10 (2006.01) C12N 9/02 (2006.01)

Patent

CA 2494845

The present invention provides novel methods of preventing, diagnosing, and treating Critical Limb Ischemia (CLI), using eNOS polypeptides and polynucleotides to modulate eNOS activity in cells. Wild-type and mutant eNOS polypeptides, and polynucleotides encoding such polypeptides, are provided for use in the methods of the present invention. The eNOS mutant polypeptides of the present invention have at least one mutation corresponding to a site in a functional domain of a mammalian eNOS that is phosphorylated in cells.

L'invention porte sur des nouvelles méthodes de prévention, de diagnostic, et de traitement de l'ischémie aiguë des membres (CLI), au moyen de polypeptides eNOS et de polynucléotides afin de moduler l'activité eNOS dans les cellules. Des polypeptides eNOS de type sauvage et mutant, et des polynucléotides codant ces polypeptides sont utilisés dans les méthodes de l'invention. Les polypeptides mutants eNOS de l'invention présentent au moins une mutation correspondant à un site dans un domaine fonctionnel d'un eNOS mammifère qui est phosphorylé dans les cellules.

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