Gene therapy for effector cell regulation

Details Gene therapy for effector cell regulation Gene therapy for effector cell regulation

C - Chemistry, Metallurgy

12

N

C12N 15/31 (2006.01) A61K 9/127 (2006.01) A61K 31/70 (2006.01) A61K 39/00 (2006.01) A61K 39/04 (2006.01) A61K 39/39 (2006.01) A61K 48/00 (2006.01) C07K 14/31 (2006.01) C12N 15/19 (2006.01) C12N 15/62 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2221305

The present invention provides a nucleic acid-based therapeutic composition to treat an animal with disease by controlling the activity of effector cells, including T cells, macrophages, monocytes and/or natural killer cells, in the animal. Therapeutic compositions of the present invention include superantigen- encoding nucleic acid molecules, either in the presence or absence of a cytokine-encoding nucleic acid molecule and/or chemokine-encoding nucleic acid molecules, depending upon the disease being treated. The present invention also relates to an adjuvant for use with nucleic acid-based vaccines. Adjuvant compositions of the present invention include an immunogen combined with superantigen-encoding nucleic acid molecules, either in the presence or absence of a cytokine-encoding nucleic acid molecule and/or chemokine-encoding nucleic acid molecules.

L'invention concerne une composition thérapeutique à base d'acide nucléique destinée au traitement d'un animal atteint d'une maladie, consistant à réguler l'activité de cellules effectrices, c'est-à-dire les lymphocytes T, les macrophages, les monocytes et/ou les cellules tueuses naturelles chez l'animal. Les compositions thérapeutiques de l'invention comprennent des molécules d'acide nucléique codant un super antigène, soit en présence soit en l'absence d'une molécule d'acide nucléique codant la cytokine et/ou de molécules d'acide nucléique codant la chimiokine, selon la maladie traitée. L'invention concerne également un adjuvant destiné à être utilisé avec des vaccins à base d'acide nucléique. Les compositions d'adjuvant de la présente invention comprennent un immunogène combiné à des molécules d'acide nucléique codant un super antigène, soit en présence soit en l'absence d'une molécule d'acide nucléique codant la cytokine et/ou de molécules d'acide nucléique codant la chémokine.

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