Gene therapy for myocardial ischemia

Details Gene therapy for myocardial ischemia Gene therapy for myocardial ischemia

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01) A61K 31/70 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C12N 7/01 (2006.01) C12N 15/12 (2006.01) C12N 15/861 (2006.01)

Patent

CA 2221710

The transgene-inserted replication-deficit adenoviral vector is effectively used in in vivo gene therapy for myocardial ischemia in a protective way, by a single intracoronary injection directly conducted deeply in the lumen of the coronary arteries in an amount sufficient for transfecting all cell types in the affected region, including cardiac myocytes.

Utilisation efficace du vecteur adénoviral présentant un déficit de réplication et inséré par transgène en thérapie génique in vivo pour protéger de l'ischémie myocardique, par une seule injection intracoronaire, directement introduite profondément dans la lumière des artères coronaires, en une quantité suffisante pour transfecter tous les types de cellules dans la région affectée, y compris les myocytes cardiaques.

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