Gene therapy for pituitary adenoma and other endocrine...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/86 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C12N 9/02 (2006.01) C12N 15/52 (2006.01)

Patent

CA 2221604

Virus vectors containing selected genes encoding proteins capable of modulating pituitary tumor or gland physiology and methods for using these vectors in the treatment of pituitary adenomas, pituitary hyperfunction and hypofunction, dysfunction of the hypothallamic/pituitary axis, and neuroendocrine diseases mediated by the pituitary gland are provided.

Des vecteurs viraux, qui contiennent des gènes sélectionnés codant des protéines, peuvent moduler la physiologie d'une tumeur pituitaire ou de l'hypophyse. Des procédés permettent d'utiliser de tels vecteurs dans le traitement des adénomes hypophysaires, des dysfonctionnements de l'axe hypothalame-hypophysaire et des maladies neuro-endocriniennes induites par l'hypophyse.

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