Gene therapy for proliferative vitreoretinopathy

Details Gene therapy for proliferative vitreoretinopathy Gene therapy for proliferative vitreoretinopathy

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61K 31/70 (2006.01) A61K 38/45 (2006.01) A61K 38/50 (2006.01)

Patent

CA 2251078

A method of treating ocular disorders (such as, for example, proliferative vitreoretinopathy or PVR) associated with replicating ocular cells by transfecting replicating ocular cells in vivo with a polynucleotide encoding an agent which is capable of providing for the inhibition, prevention, or destruction of the growth of the replicating ocular cells upon expression of the agent. The agent may be a viral thymidine kinase, and the polynucleotide encoding the agent may be contained in a retroviral vector. Once the replicating ocular cells are transduced with the retroviral vector, the patient is given a chemotherapeutic or interaction agent, such as ganciclovir, which kills the transfected replicating ocular cells.

Méthode de traitement des troubles oculaires ( par exemple, la vitréorétinopathie proliférative) associée à la réplication des cellules oculaires par la transfection in vivo des cellules oculaires en cours de reproduction avec un polynucléotide codant un agent qui est capable d'assurer l'inhibition, la prévention ou la destruction de la croissance des cellules oculaires en cours de reproduction par l'expression de l'agent. L'agent peut être une thymidine kinase virale alors que le polynucléotide codant l'agent peut être contenu dans le vecteur rétroviral. Une fois que les cellules oculaires en cours de reproduction ont été transduites par le vecteur rétroviral, le patient reçoit un agent chimiothérapeutique ou interactif, comme le ganciclovir, qui tue les cellules oculaires transduites.

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