Gene therapy for renal failure

Details Gene therapy for renal failure Gene therapy for renal failure

C - Chemistry, Metallurgy

12

N

C12N 15/63 (2006.01) A61K 48/00 (2006.01) C07K 14/51 (2006.01) C12N 15/12 (2006.01) C12N 15/18 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2629522

The present invention relates to recombinant vectors expressing the BMP-7 polypeptide in host cells and to pharmaceutical compositions comprising such recombinant vectors. The invention also encompasses methods for prevention and/or treatment of both acute and chronic renal failure in mammals, advantageously in dogs and cats, by administration of the recombinant vectors and pharmaceutical compositions of the invention.

L'invention se réfère à des vecteurs recombinés qui expriment le polypeptide BMP-7 dans des cellules hôtes, et à des compositions pharmaceutiques comprenant ces vecteurs recombinés. L'invention concerne aussi des procédés destinés à prévenir et/ou à traiter l'insuffisance rénale aiguë et chronique chez des mammifères, avantageusement chez le chien et le chat, par l'administration des vecteurs recombinés et des compositions pharmaceutiques de l'invention.

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