Gene therapy for the treatment of solid tumors using...

Details Gene therapy for the treatment of solid tumors using... Gene therapy for the treatment of solid tumors using...

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C07K 14/55 (2006.01) C07K 14/565 (2006.01) C12N 7/01 (2006.01) C12N 15/12 (2006.01) C12N 15/19 (2006.01) C12N 15/52 (2006.01) C12N 15/864 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2247806

The use of recombinant adeno-associated virus (AAV) virions for the treatment of solid tumors is disclosed. The invention provides for the use of recombinant AAV virions to deliver an AAV vector containing a drug- susceptibility gene and a second gene capable of providing an ancillary effect to solid tumor cells. The second gene can be used to enhance the immunogenicity of the transduced tumor cell. Alternatively, the second gene can be used to provide a tumorstatic effect. The invention also provides for the use of recombinant AAV virions to deliver an interferon gene, or a tumor suppressor gene to provide a therapeutic effect in a transduced tumor cell.

L'invention concerne l'utilisation de virions de virus adéno-associés (VAA) pour traiter les tumeurs solides. Elle permet d'utiliser des virions de VAA recombinés pour administrer un vecteur de VAA contenant un gène de sensibilité médicamenteuse et un second gène pouvant avoir une activité auxiliaire sur les cellules de tumeurs solides. Le second gène peut être utilisé pour accroître l'immunogénicité de la cellule tumorale transduite. Il peut également être utilisé pour son activité tumorostatique. L'invention permet également d'utiliser des virions de VAA recombinés pour administrer un gène d'interféron ou un gène suppresseur de tumeur, de façon à obtenir un effet thérapeutique dans une cellule tumorale transduite.

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