C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 31/70 (2006.01) A61K 35/12 (2006.01) A61K 38/36 (2006.01) A61K 48/00 (2006.01) C07K 14/745 (2006.01) C12N 5/10 (2006.01) C12N 15/85 (2006.01) C12N 15/86 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2197427
A method to genetically modify mammalian cells to render them less susceptible to an inflammatory or immunological stimulus, particularly to alleviate thrombogenicity in endothelial cells subject to inflammatory or immune activation, is described, comprising genetically modifying the cells by inserting therein DNA encoding thrombomodulin and thereby expressing functional thrombomodulin from these cells under cellular activating conditions. The method, which can be carried out either in vivo or in vitro (ex vivo), is indicated for use in transplantation as well as to treat systemic or local inflammatory conditions characterized by thrombosis.
Procédé de modification génétique de cellules de mammifères afin de rendre celles-ci moins sensibles à un stimulus inflammatoire ou immunologique, notamment pour diminuer la tendance des cellules endothéliales à provoquer une coagulation lorsque celles-ci sont soumises à une activation inflammatoire ou immune, ce procédé consistant à modifier génétiquement les cellules en insérant dans celles-ci l'ADN codant la thrombomoduline aux fins d'expression de la thrombomoduline fonctionnelle à partir de ces cellules, dans des conditions d'activation cellulaire. On peut effectuer ce procédé, soit in vivo soit in vitro (ex vivo), celui-ci étant indiqué dans une transplantation, de même que dans le traitement d'états systémiques ou inflammatoires locaux caractérisés par la thrombose.
Bach Fritz H.
Wrighton Christopher
Beth Israel Deaconess Medical Center Inc.
Kirby Eades Gale Baker
New England Deaconess Hospital Corporation
Sandoz Ltd.
The Beth Israel Hospital Association
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