Gene therapy involving concurrent and repeated...

Details Gene therapy involving concurrent and repeated... Gene therapy involving concurrent and repeated...

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61K 31/70 (2006.01) A61K 38/13 (2006.01) C12N 15/861 (2006.01)

Patent

CA 2200869

A method of effecting a gene therapy treatment in a host which comprises the steps of: (a) administering to a host concurrently (i) an adenoviral vector including at least one DNA sequence encoding a therapeutic agent and (ii) an immunosuppressive agent; (b) discontinuing the administration of said adenoviral vector and said immunosuppressive agent; and (c) repeating the administration of the adenoviral vector and the immunosuppressive agent at least once. The repeated course of treatment of administration of an adenoviral vector and an immunosuppressive agent provides for continued or increased expression of the at least one DNA sequence encoding the therapeutic agent.

L'invention est une méthode de traitement de thérapie génique d'un hôte qui comporte les opérations suivantes : a) administration concomitante à l'hôte i) d'un vecteur adénoviral comportant au moins une séquence d'ADN codant un agent thérapeutique et ii) un agent immunosuppresseur, b) discontinuation de l'administration du vecteur adénoviral et de l'agent immunosuppresseur cités, et c) reprise au moins une fois de l'administration du vecteur adénoviral et de l'agent immunosuppresseur. La répétition du traitement consistant à administrer un vecteur adénoviral et un agent immunosuppresseur permet d'assurer un codage continu de l'agent thérapeutique par une séquence d'ADN au moins ou d'accentuer ce codage.

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