C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/18 (2006.01) A61K 31/70 (2006.01) A61K 35/34 (2006.01) A61K 48/00 (2006.01) C07K 14/505 (2006.01) C12N 5/10 (2006.01) C12N 15/85 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2183551
The present invention involves gene therapy for the enhancement of red blood cell production. The delivery and expression of the erythropoietin gene, elicits a stable increase in red blood cell production. The present invention includes recombinant delivery vectors, compositions, alternative gene therapy strategies, and transfected cells which express sufficient erythropoietin to present a physiologically significant systemic response.
La présente invention concerne la thérapie génique pour améliorer la production de globules rouges. L'apport et l'expression du gène de l'érythropoïétine déclenchent une augmentation stable de la production de globules rouges. La présente invention traite également de vecteurs d'apport de recombinaison, de compositions, d'autres stratégies de thérapie génique, et de cellules transfectées qui expriment assez d'érythropoïétine pour présenter une réponse systémique physiologiquement significative.
Hamamori Yasuo
Kedes Laurence H.
Samal Babru B.
Amgen Inc.
Gowling Lafleur Henderson Llp
The University Of Southern California
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