Gene transcription and ionizing radiation: methods and...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/85 (2006.01) A61K 31/7088 (2006.01) A61K 48/00 (2006.01) C12N 5/10 (2006.01) C12N 15/11 (2006.01) C12N 15/63 (2006.01) C12N 15/67 (2006.01) A61K 38/00 (2006.01) C07K 14/525 (2006.01) C07K 14/82 (2006.01)

Patent

CA 2144406

The present invention provides a DNA molecule comprising a radiation responsive enhancer-promoter operatively linked to an encoding region that encodes at least one polypeptide. An encoding region can comprise a single encoding sequence for a polypeptide or two or more encoding sequences encoding DNA binding, activation or repression domains of a transcription factor. Processes for regulating polypeptide expression and inhibiting tumor growth using such DNA molecules are also provided.

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