Gene transfer-mediated angiogenesis therapy

Details Gene transfer-mediated angiogenesis therapy Gene transfer-mediated angiogenesis therapy

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01) A61K 31/70 (2006.01) A61K 38/18 (2006.01) A61K 38/19 (2006.01) A61K 48/00 (2006.01) C07K 14/50 (2006.01) C12N 15/861 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2188575

The transgene-inserted replication-deficit adenovirus vector is effectively used in in vivo gene therapy for peripheral vascular disease and heart disease, including myocardial ischemia, by a single intra-femoral artery or intracoronary injection directly conducted deeply in the lumen of the one or both femoral or coronary arteries (or graft vessels) in an amount sufficient for transfecting cells in a desired region.

La transgénèse au moyen d'un vecteur adénovirus à déficit de réplication est utilisée de façon efficace dans la thérapie génique in vivo destinée à traiter les acrosyndromes vasculaires et les maladies cardiaques, notamment l'ischémie myocardique, au moyen d'une injection unique dans l'artère fémorale ou dans la coronaire, effectuée directement en profondeur dans la lumière de l'une des artères fémorale ou coronaire ou les deux (ou des vaisseaux greffés), en quantité suffisante pour assurer la transfection des cellules dans la région voulue.

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