Gene transfer vectors for treating autoimmune diseases and...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/62 (2006.01) A61K 38/43 (2006.01) A61K 39/00 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2387146

The invention relates to a gene transfer vector, comprising at least one nucleic acid molecule comprising a first nucleic acid sequence which codes for one or more ligands that trigger apoptosis, a second nucleic acid sequence which codes for one or more antigens, optionally, a third nucleic acid sequence which codes for one or more anti-apoptosis molecules, and optionally, a fourth nucleic acid sequence which codes for one or more suicide enzymes.

L'invention concerne un vecteur de transfert de gènes comprenant au moins une molécule d'acide nucléique, contenant une première séquence d'acide nucléique, codante pour au moins un ligand déclenchant l'apoptose, une deuxième séquence d'acide nucléique, codante pour au moins un antigène et éventuellement, une troisième séquence d'acide nucléique, codante pour au moins une molécule d'antiapoptose, et éventuellement une quatrième séquence d'acide nucléique, codante pour l'enzyme/les enzymes suicide(s).

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