Gene transfer with adenoviruses having modified fiber proteins

Details Gene transfer with adenoviruses having modified fiber proteins Gene transfer with adenoviruses having modified fiber proteins

A - Human Necessities

61

K

A61K 35/76 (2006.01) A61K 48/00 (2006.01) C07K 14/075 (2006.01) C12N 15/09 (2006.01) C12N 15/63 (2006.01) C12N 15/85 (2006.01) C12N 15/86 (2006.01) C12N 15/861 (2006.01) C12N 15/88 (2006.01)

Patent

CA 2289215

A method of transferring at least one DNA sequence into cells by transducing the cells, in vivo or ex vivo, with a modified adenovirus. The adenovirus, prior to modification, is of a first serotype. In the modified adenovirus, at least a portion of the fiber, and in particular the head portion, is removed from the adenovirus of the first serotype and replaced with a portion, in particular the head portion, of the fiber of an adenovirus of a second serotype. Such method is useful in transducing cells which may be refractory to the adenovirus of the first serotype, yet include a receptor which binds to the head portion of the fiber of the adenovirus of the second serotype.

Procédé permettant de transférer au moins une séquence d'ADN dans des cellules par transduction des cellules, in vivo ou ex vivo, avec un adénovirus modifié. Avant sa modification, l'adénovirus est d'un premier sérotype. Dans l'adénovirus modifé, au moins une partie de la fibre, et plus particulièrement la partie tête, est éliminée de l'adénovirus du premier sérotype et remplacée par une partie, plus particulièrement la partie de tête, de la fibre d'un adénovirus d'un deuxième sérotype. Ce procédé est utile dans la transduction de cellules qui peuvent être résistantes à l'adénovirus du premier sérotype, mais qui comprennent cependant un récepteur qui se lie à la partie tête de la fibre de l'adénovirus du deuxième sérotype.

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