C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
167/101, 150/11,
C12Q 1/02 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) C07K 1/14 (2006.01) C07K 7/08 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) G01N 1/34 (2006.01) G01N 33/574 (2006.01) A61K 38/00 (2006.01)
Patent
CA 1336404
The invention relates to a cancer recognition factor (SCM-factor), its use and method of preparation. The SCM-factor of the invention is characterized as a low molecular weight peptide which is distinguished by its ability to produce a ten percent to fifty percent decrease in the intracellular fluorescein fluorescence polarization value of SCM-responding lymphocytes derived from the blood samples of donors afflicted with cancer. The SCM-factor is also characterized by its ability, after prolonged contact with SCM-responding lymphocytes, to modify the SCM-response of lymphocytes from donors not afflicted with cancer so that such lymphocytes respond in the SCM-test in all respects like lymphocytes from donors afflicted with cancer. The SCM-factor is isolated from a body fluid such as blood or urine by first subjecting the body fluid to ultrafiltration through a filter with a 1000 Dalton molecular weight cutoff. Following ultrafiltration the filtrate may be lyophilized or stored at 4°C or immediately purified by elution with distilled water through a chromatographic column and collecting elution fractions of between 0.3 and 0.5 Ve/Vt. The collected fractions may be further purified by elution with aqueous ammonium bicarbonate through a chromatographic column saving the elution fractions of between 0.4 and 0.6 Ve/Vt. If desired the samples may be even further purified by passage through a column packed with anion exchange material followed by reverse phase high pressure liquid chromatography purification. The SCM-factor is used for general screening of blood samples for the presence of malignancy in the donor body.
560590
Cercek Boris
Cercek Lea
Cercek Boris
Cercek Lea
Macrae & Co.
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