Generating d-peptides: methods and compositions

Details Generating d-peptides: methods and compositions Generating d-peptides: methods and compositions

C - Chemistry, Metallurgy

07

K

C07K 16/00 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) C07K 2/00 (2006.01) C07K 4/00 (2006.01) C07K 14/00 (2006.01) G01N 33/53 (2006.01) G01N 33/563 (2006.01) G01N 33/566 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2234723

Methods of making and using D-antibodies and D-peptides are provided. The D- peptides or D-antibodies are analogs of ligands or receptors capable of specifically binding L-peptides, peptides containing both L-amino acids and D- amino acids, chiral and achiral non-naturally occurring peptides, and chiral and achiral non-peptide compounds. The D-peptides or D-antibodies are resistant to proteolysis in the gut and throughout the body and are less immunogenic than their L-polypeptide or L-antibody counterparts. Methods for producing such D-peptides or D-antibodies are provided.

L'invention porte sur des procédés de production et d'utilisation d'anticorps D et de peptides D. Lesdits anticorps et peptides sont des analogues de ligands ou de récepteurs pouvant se fixer spécifiquement aux peptides L, aux peptides contenant à la fois des L-aminoacides et des D-aminoacides de peptides chiraux et non chiraux non naturels, et à des composés chiraux et non chiraux non peptidiques. Lesdits peptides et anticorps résistent à la protéolyse dans l'intestin et dans le corps et sont moins immunogènes que leurs contreparties, les anticorps L et les peptides L. L'invention porte également sur leur procédé de fabrication.

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