C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/06 (2006.01) A61K 35/14 (2006.01) A61P 35/00 (2006.01) C12N 5/08 (2006.01)
Patent
CA 2385792
A dendritic cell (DC) composition and a method of obtaining such a composition by isolating and culturing human peripheral blood mononuclear cells (PBMC) is described, together with methods of identifying and isolating DC at two different stages of maturation [the DC precursor (DCP) stage and the mature DC stage]. Also described are methods of activating T-cells employing such a DC composition.
L'invention concerne une composition de cellules dendritiques (CD) et un procédé permettant d'obtenir une telle composition par isolation et culture de cellules mononucléaires du sang périphérique (PBMC = Peripheral Blood Mononuclear Cells) humain, ainsi que des procédés d'identification et d'isolation des CD à deux stades différents de la maturation [le stade précurseur et à maturité]. L'invention concerne également des procédés d'activation des lymphocytes T au moyen d'une composition de cellules dendritiques.
Monji Tatsue
Peshwa Madhusudan V.
Dendreon Corporation
Gowling Lafleur Henderson Llp
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