C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61P 35/00 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C07K 16/46 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) G01N 33/566 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2625681
The present invention provides novel antibodies and methods for using recombinant antigen-binding regions and antibodies and functional fragments containing such antigen-binding regions that are specific for CD38, which plays an integral role in various disorders or conditions. These methods take advantage of newly discovered antibodies and surprising properties of such antibodies, such as the ability to bind CD38 of minipig origin and the ability to induce, by cross-linking, specific killing of cells that express CD38. These antibodies as well as the novel methods for using those antibodies can be used to treat, for example, hematological malignancies such as multiple myeloma.
La présente invention concerne de nouveaux anticorps et de nouvelles méthodes d'utilisation de régions de liaison aux antigènes de recombinaison ainsi que des anticorps et des fragments fonctionnels contenant lesdites régions de liaison aux antigènes qui sont spécifiques de la molécule CD38, qui joue un rôle primordial dans divers troubles ou affections. Lesdites méthodes consistent à tirer profit d'anticorps nouvellement découverts et des propriétés surprenantes desdits anticorps, comme l'aptitude à se lier à la CD38 provenant du porc miniature et l'aptitude à induire, par réticulation, la mort spécifique de cellules exprimant la CD38. Lesdits anticorps ainsi que les nouvelles méthodes d'utilisation desdits anticorps peuvent être utilisés pour traiter, par exemple, des malignités hématologiques telles que le myélome multiple.
Jaeger Ute
Tesar Michael
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Morphosys Ag
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