C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) A61K 39/395 (2006.01) C12N 1/15 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 15/09 (2006.01) C12P 21/08 (2006.01) G01N 33/563 (2006.01) G01N 33/577 (2006.01)
Patent
CA 2754591
The present invention provides humanized antibodies that immunospecifically recognize human 9 integrin. Some of these antibodies inhibit the biological functions of the 9 integrin, thereby exhibiting therapeutic effects on various disorders or diseases that are associated with 9 integrin, including cancer, e.g., the growth and metastasis of a cancer cell, and inflammatory diseases, e.g., rheumatoid arthritis, osteoarthritis, hepatitis, bronchial asthma, fibrosis, diabetes, arteriosclerosis, multiple sclerosis, granuloma, an inflammatory bowel disease (ulcerative colitis and Crohn's disease), an autoimmune disease, and so forth.
La présente invention concerne des anticorps humanisés qui reconnaissent immunospécifiquement l'intégrine 9 humaine. Certains de ces anticorps inhibent les fonctions biologiques de l'intégrine 9, révélant de ce fait des effets thérapeutiques sur divers troubles ou maladies qui sont associés à l'intégrine 9, y compris le cancer, par exemple, la croissance et la métastase d'une cellule cancéreuse, et des maladies inflammatoires, par exemple, l'arthrite rhumatoïde, l'ostéoarthrite, l'hépatite, l'asthme bronchique, la fibrose, le diabète, l'artériosclérose, la sclérose en plaques, le granulome, une maladie intestinale inflammatoire (la rectocolite hémorragique et la maladie de Crohn), une maladie auto-immune, et ainsi de suite.
Harada Tatsuhiro
Kumar Shankar
Tso J. Yun
Tsurushita Naoya
Gene Techno Science Co. Ltd.
Kaken Pharmaceutical Co. Ltd.
Smart & Biggar
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