C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/00 (2006.01) C12N 15/85 (2006.01)
Patent
CA 2638117
The present invention relates to a method for the generation of VH heavy chain- only antibodies in a transgenic non-human mammal. In particular, the present invention relates to a method for the production of a VH heavy chain-only antibody in a transgenic non-human mammal comprising the step of expressing more than one heterologous VH heavy chain locus in that mammal.
La présente invention concerne une méthode pour produire des anticorps à chaîne lourde VH seulement chez un mammifère transgénique non humain. En particulier, la présente invention concerne une méthode pour la production d'un anticorps à chaîne lourde VH seulement chez un mammifère transgénique non humain qui comprend l'étape d'exprimer plus d'un lieu de chaîne lourde VH hétérologue chez ce mammifère.
Grosveld Franklin Gerardus
Janssens Richard Wilhelm
Erasmus University Medical Center Rotterdam
Mbm Intellectual Property Law Llp
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