C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 7/01 (2006.01) A61K 39/12 (2006.01) C12N 15/39 (2006.01) C12N 15/48 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2054379
(54)Title: GENERATION OF HYBRID GENES AND PROTEINS BY VIRUS-MEDIATED RECOMBINATlON (57) Abstract The ability of viruses to undergo recombi- nation within tandemly arranged homologous se- quenecs can be utilized to generate chimeric gen- es and proteins. Tandemly arranged homologous sequences will rapidly degenerate in a random fashion to yieid a single copy comprised of por- tions of both original sequences. Therefore, a rec- Image ombinant virus which contains two related but non-identical genes in tandem array yields a pop- ulation of recombinant viruses which contain a spectrum of hybrid sequences derived from rec- ombination between the original genes. The vi- ruses, therefore, contain hybrid DNA sequences that encode proteins with new epitopes or differ- ent combinations of epitopes. Vaccines are de- rived which may afford protection against a broad spectrum of antigen types.
Gritz Linda R.
Panicali Dennis L.
Applied Biotechnology Inc.
Ogilvy Renault
LandOfFree
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