Generation of library of soluble random polypeptides linked...

C - Chemistry – Metallurgy – 40 – B

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C40B 50/00 (2006.01) C40B 40/10 (2006.01) C40B 50/06 (2006.01) C40B 40/08 (2006.01)

Patent

CA 2677804

Methods and compositions are provided for producing libraries of soluble random polypeptides. In the methods, the fraction of hydrophilic residues in the polypeptide is controlled so as to maintain the solubility of the polypeptide constructs.

L'invention concerne des procédés et des compositions pour la production de bibliothèques de polypeptides aléatoires solubles. Dans ces procédés, la fraction des résidus hydrophiles dans le polypeptide est contrôlée de sorte à maintenir la solubilité des constructions de polypeptide.

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