C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/35 (2006.01) A61K 39/235 (2006.01) C07K 14/015 (2006.01) C12N 5/10 (2006.01) C12N 15/861 (2006.01) C12N 15/864 (2006.01) C12Q 1/70 (2006.01)
Patent
CA 2369985
A complete virus-mediated system for recombinant AAV production including: (a) a first recombinant adenovirus encoding one or more AAV REP78/68 polypeptides and one or more viral capsid polypeptides; (b) a second recombinant adenovirus encoding a gene of interest and including AAV inverted terminal repeats, wherein the AAV inverted terminal repeats flank the gene of interest; (c) viral helper functions; and (d) a host cell transduced with the first recombinant adenovirus, the second recombinant adenovirus, and the viral helper functions.
Li Chuan-Yuan
Zhang Xiuwu
Duke University
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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