C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 7/01 (2006.01) A61K 31/335 (2006.01) A61K 31/365 (2006.01) A61K 31/7048 (2006.01) A61K 31/724 (2006.01) A61K 39/12 (2006.01) C07K 14/08 (2006.01) C12N 7/04 (2006.01) C12N 15/40 (2006.01) C12Q 1/70 (2006.01)
Patent
CA 2465895
In this application is described a method for the formation of filovirus-like particles for both Ebola and Marburg and their use as a diagnostic and therapeutic agent as well as a filovirus vaccine. Also described is the association of Ebola and Marburg with lipid rafts during assembly and budding, and the requirement of functional rafts for entry of filoviruses into cells.
Cette invention porte sur un procédé de formation de particules similaires aux filovirus d'Ebola et de Marburg et leur utilisation en tant qu'agents thérapeutiques ou diagnostiques et en tant que vaccins de filovirus. Elle concerne aussi l'association d'Ebola et Marburg avec des radeaux lipidiques, utilisés pendant l'assemblage et le bourgeonnement, et l'exigence d'utiliser des radeaux lipidiques pour l'entrée des filovirus dans les cellules.
Aman M. Javad
Bavari Sina
Schmaljohn Alan L.
Borden Ladner Gervais Llp
U.s. Army Medical Research Institute Of Infectious Diseases Depa
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