Generation of xenogeneic antibodies

Details Generation of xenogeneic antibodies Generation of xenogeneic antibodies

C - Chemistry, Metallurgy

12

N

C12N 5/10 (2006.01) A01K 67/027 (2006.01) A61K 39/395 (2006.01) C07K 16/00 (2006.01) C07K 16/12 (2006.01) C07K 16/24 (2006.01) C07K 16/28 (2006.01) C07K 16/46 (2006.01) C12N 15/85 (2006.01) C12P 21/08 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2050918

2050918 9110741 PCTABS00006 The subject invention provides non-human mammalian hosts characterized by inactivated endogenous Ig loci and functional human Ig loci for response to an immunogen to produce human antibodies or analogs thereof. The hosts are produced by repetitive transformations of embryonic stem cells by homologous recombination, preferably in conjunction with breeding. Different strategies are employed for recombination of the human loci randomly or at analogous host loci.

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