Generation of xenogeneic antibodies

Details Generation of xenogeneic antibodies Generation of xenogeneic antibodies

C - Chemistry, Metallurgy

12

N

C12N 15/90 (2006.01) A01K 67/027 (2006.01) C07K 16/00 (2006.01) C12N 5/10 (2006.01) C12N 15/85 (2006.01) C12N 15/87 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2140638

The subject invention provides non-human mammalian hosts characterized by inactivated endogenous Ig loci and functional human Ig loci for response to an immunogen to produce human antibodies or analogs thereof. The hosts are produced by multiple genetic modifications of embryonic cells in conjunction with breeding. Different strategies are employed for recombination of the human loci randomly or a1 analogous host loci. Chimeric and transgenic mammals, particularly mice, are provided, having stably integrated large, xenogeneic DNA segments. The segments are introduced by fusion with yeast spheroplasts comprising yeast artificial chromosomes (YACs) which include the xenogeneic DNA segments and a selective marker such as HPRT, and embryonic stem cells.

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