Generic probes for the detection of phosphorylated sequences

Details Generic probes for the detection of phosphorylated sequences Generic probes for the detection of phosphorylated sequences

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/44 (2006.01) A61K 31/47 (2006.01)

Patent

CA 2573869

Generic probes that bind to phosphorylated amino acid residues are provided as well as methods employing the probes for screening for kinase inhibitory activity, kinase activity, and phosphatase activity. Methods for distinguishing serine/threonine kinase phosphorylation from tyrosine kinase phosphorylation are also provided.

L'invention concerne des sondes génériques qui se lient à des résidus d'acides aminés phosphorylés, et des procédés d'utilisation de ces sondes en vue de détecter l'activité d'inhibition de kinases, l'activité de kinases et l'activité de phosphatases. L'invention concerne aussi des procédés permettant de distinguer la phosphorylation d'une sérine/thréonine kinase de celle d'une tyrosine kinase.

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