Genes and polypeptides relating to breast cancers

Details Genes and polypeptides relating to breast cancers Genes and polypeptides relating to breast cancers

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 31/7088 (2006.01) A61K 31/713 (2006.01) A61K 38/17 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C07H 21/02 (2006.01) C07K 14/43 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C07K 19/00 (2006.01) C12N 15/12 (2006.01) C12Q 1/02 (2006.01) C12Q 1/48 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2660438

The present application provides novel human genes A7322, whose expression is markedly elevated in breast cancer. The present application also provides human genes F3374 whose expression is markedly elevated in breast cancer. These genes and polypeptides encoded thereby can be used, for example, in the diagnosis of breast cancer, and as target molecules for developing drugs against breast cancer. The invention features methods of screening for modulators of the kinase activity of PBK/TOPK. The invention further provides methods of screening for agents to prevent or treat cancer, such as breast cancer.

L'invention concerne de nouveaux gènes humains A7322 dont l'expression est notablement élevée dans le cancer du sein. L'invention concerne aussi des gènes humains F3374 dont l'expression est notablement élevée dans le cancer du sein. Ces gènes et ces polypeptides ainsi codés peuvent être utilisés, par exemple, dans le diagnostic du cancer du sein et comme molécules cibles pour le développement de médicaments contre le cancer du sein. L'invention porte également sur des procédés de criblage de modulateurs de l'activité kinase de PBK/TOPK, ainsi que sur des procédés de criblage d'agents destinés à la prévention ou au traitement du cancer tel que le cancer du sein.

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