Genes and polypeptides relating to human colon cancers

Details Genes and polypeptides relating to human colon cancers Genes and polypeptides relating to human colon cancers

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 31/713 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01) C07K 14/47 (2006.01) C07K 16/32 (2006.01) C12N 15/12 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2488404

The present application provides novel human genes RNF43 whose expression is markedly elevated in colorectal cancers, as well as CXADRL1 and GCUD1 whose expression is markedly elevated in gastric cancers compared to corresponding non-cancerous tissues. The genes and polypeptides encoded by the genes can be used, for example, in the diagnosis of a cell proliferative disease, and as target molecules for developing drugs against the disease.

La présente invention concerne les nouveaux gènes humains RNF43 dont l'expression est nettement élevée dans les cancers colorectaux, ainsi que CXADRL1 et GCUD1 dont l'expression est nettement élevée dans les cancers de l'estomac comparativement aux tissus non cancéreux correspondants. Les gènes et les polypeptides codés par les gènes peuvent être utilisés, par exemple, dans le diagnostic d'une maladie proliférative cellulaire et en tant que molécules cibles utiles pour mettre au point des médicaments s'opposant à la maladie.

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