Genes and polypeptides relating to human myeloid leukemia

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C07H 21/00 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 14/82 (2006.01) C07K 16/18 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/574 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2500405

The present application provides novel human genes RHBDF1 whose expression is markedly elevated in CML and AML compared to normal peripheral blood cell, and lung adenocarcinoma compared to normal lung cell. The genes and polypeptides encoded by the genes can be used, for example, in the diagnosis of a cell proliferative disease, and as target molecules for developing drugs against the disease.

La présente invention concerne de nouveaux gènes humains appelés RHBDF1, dont l'expression est notablement élevée dans la LMC ou la LAM, par comparaison avec des cellules du sang périphérique saines, et dans l'adénocarcinome pulmonaire par comparaison avec des cellules pulmonaires saines. Les gènes et les polypeptides codés par ces gènes peuvent être utilisés, par exemple, pour diagnostiquer une maladie à prolifération cellulaire, ou comme molécules cibles destinées à la mise au point de médicaments contre cette maladie.

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