Genes and polypeptides relating to prostate cancers

Details Genes and polypeptides relating to prostate cancers Genes and polypeptides relating to prostate cancers

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07H 21/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12P 21/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2500859

The present application provides novel human gene MICAL2-PV whose expression is markedly elevated in prostate cancers. Furthermore, it provides polypeptides encoded by the gene as well as polypeptides encoded by PCOTH which expression was also discovered to be elevated in prostate cancers. The genes and polypeptides encoded by the genes can be used, for example, in the diagnosis of prostate cancers, as target molecules for developing drugs against the disease, and for attenuating cell growth of prostate cancer.

Cette invention, qui a trait à un nouveau gène humain MICAL2-PV dont l'expression est très élevée dans le cas de cancer de la prostate, concerne également des polypeptides codés par ce gène ainsi que des polypeptides codés par le gène PCOTH dont l'expression est élevée dans le cas de cancers de la prostate. Il est possible, notamment, d'utiliser les gènes et les polypeptides codés par lesdits gènes pour diagnostiquer un cancer de la prostate, comme molécules cibles afin de mettre au point des médicaments contre cette maladie ainsi que pour limiter la croissance cellulaire dans le cas de cancer de la prostate.

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