C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/61 (2006.01) C07K 14/36 (2006.01) C07K 16/12 (2006.01) C12N 9/90 (2006.01) C12N 15/31 (2006.01) C12N 15/52 (2006.01) C12P 21/02 (2006.01)
Patent
CA 2415339
Genes and proteins involved in the biosynthesis of polyketides by microorganisms, including the genes and proteins forming the biosynthetic loci for the polyketide dorrigocin from Streptomyces platensis subsp. rosaceus and the polyketide lactimidomycin from Streptomyces amphibiosporus. The genes and proteins allow direct manipulation of dorrigocin, lactimidomycin and related chemical structures via chemical engineering of the enzymes involved in the biosynthesis of dorrigocin and lactimidomycin.
L'invention concerne des gènes et des protéines impliqués dans la biosynthèse de polyketides par des microorganismes, y compris des gènes et des protéines formant les loci participant à la biosynthèse de la polyketide dorrigocine de <i>Streptomyces platensis</i> de la sous-espèce <i>rosaceus</i> et la polyketide lactimidomycine de <i>Streptomyces amphibiosporus</i>. Ces gènes et ces protéines permettent une manipulation directe de la dorrigocine, de la lactimidomycine et de structures chimiques associées, par génie chimique des enzymes impliquées dans la biosynthèse de la dorrigocine et de la lactimidomycine.
Farnet Chris M.
Staffa Alfredo
Yang Xianshu
Zazopoulos Emmanuel
Ecopia Biosciences Inc.
Looper Ywe J.
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