Genes and proteins for the production of polyene polyketides

Details Genes and proteins for the production of polyene polyketides Genes and proteins for the production of polyene polyketides

C - Chemistry, Metallurgy

12

N

C12N 15/52 (2006.01) C07C 215/24 (2006.01) C07C 279/22 (2006.01) C07C 305/14 (2006.01) C07K 14/36 (2006.01) C12N 1/20 (2006.01) C12N 9/00 (2006.01) C12N 9/02 (2006.01) C12N 9/10 (2006.01) C12N 9/16 (2006.01) C12N 9/88 (2006.01) C12N 15/31 (2006.01) C12N 15/53 (2006.01) C12N 15/54 (2006.01) C12N 15/55 (2006.01) C12N 15/60 (2006.01) C12P 7/42 (2006.01) C12P 11/00 (2006.01) C12P 13/00 (2006.01) C12P 19/44 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2453071

This invention relates to a new class of polyene polyketides, their pharmaceutically acceptable salts and derivatives, and to methods for obtaining the compounds. One method of obtaining these compounds is by cultivation of novel strains of Streptomyces aizunensis; another method involves expression of biosynthetic pathway genes in transformed host cells. The present invention further relates to the novel strains of Streptomyces aizunensis used to produce these compounds, to the use of these compounds and their pharmaceutically acceptable salts and derivatives as pharmaceuticals, in particular to their use as inhibitors of fungal cell growth and cancer cell growth. The invention also relates to pharmaceutical compositions comprising these novel polyketides or a pharmaceutically acceptable salts or derivatives thereof. Finally, the invention relates to novel polynucleotide sequences and their encoded proteins, which are involved in the biosynthesis of these novel polyketides.

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