C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01)
Patent
CA 2415199
The invention relates to genes comprising coding mononucleotide microsatellites (cMNR) or dinucleotide microsatellites (cDNR). The genes can be isolated from MSI+ tumour cells. Said genes differ from corresponding genes from non-MSI+ (tumour) cells by mutations in the cMNR or cDNR and code for gene products including neopeptides. The invention also relates to the use of the genes and their gene products for the prevention, diagnosis and/or therapy of MSI+ tumours.
La présente invention concerne des gènes ayant des microsatellites à mononucléotides codants (MNRc) ou des microsatellites à dinucléotides codants (DNRc). Les gènes peuvent être isolés des cellules tumorales à MSI+. Ils se distinguent des gènes correspondants issus des cellules (tumorales) à non MSI+ par des mutations dans les MNRc ou DNRc et sont codants pour des produits géniques englobant des néo-peptides. L'invention concerne également l'utilisation des gènes ou de leurs produits géniques aux fins de prévention, de diagnostic et/ou de thérapie de tumeurs à MSI+.
Bork Peer
Gebert Johannes
Linnebacher Michael
Worner Stefan
Yuan Yan Ping
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Knebel Doeberitz von Magnus
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