A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/51 (2006.01) A61K 31/00 (2006.01) A61K 38/00 (2006.01) A61K 38/17 (2006.01) A61K 38/18 (2006.01) A61K 38/43 (2006.01) A61K 38/46 (2006.01) A61P 21/00 (2006.01) A61P 25/00 (2006.01) C12N 1/38 (2006.01) C12N 5/08 (2006.01)
Patent
CA 2547474
The present invention relates to a method of modulating production of neurons and/or oligodendrocytes from neural progenitor cells of human white matter and to a method of treating a subject for a condition modulated by underproduction of oligodendrocytes from human white matter. Both of these methods involve administering an agonist or antagonist of one or more molecules set forth in Tables 1 and/or 2 to the neural progenitor cells. Also disclosed is a method of using an inhibitor of sterol synthesis to differentiate oligodendrocyte progenitor cells to oligodendrocytes.
L'invention concerne un procédé pour moduler la production des neurones et/ou des oligodendrocytes des cellules précurseurs neuronales de matière blanche humaine ainsi qu'un procédé pour traiter un sujet souffrant d'un état pathologique modulé par sous production d'oligodendrocytes de matière blanche humaine. Les deux procédés comprennent l'administration d'un agoniste et d'un antagoniste d'un ou plusieurs ensembles de molécules dans la table 1 et/ou 2 à des cellules précurseurs neuronales. L'invention concerne un procédé d'utilisation d'un inhibiteur de la synthèse de stérol, permettant de différencier des cellules précurseurs d'oligodendrocytes et d'oligodendrocytes.
Goldman Steven A.
Sim Fraser J.
Cornell Research Foundation Inc.
Gowling Lafleur Henderson Llp
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