Genes differentially expressed in cancer cells to design...

A - Human Necessities – 61 – K

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A61K 39/00 (2006.01) A61K 39/39 (2006.01) A61K 48/00 (2006.01) C07K 16/32 (2006.01) C12N 5/10 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2345440

The present invention utilized genes differentially expressed in target cells to design vaccines to generate an immune response. The method provides compositions and methods for inducing an immune response against gp 100 melanoma cells and for inducing an immune response against HER-2+ cells. Cancer vaccines and adoptive immunotherapeutic methods to treat and prevent conditions associated with the presence of these cells in a subject also are provided. The methods can be practiced by administering the appropriate gene or cancer vaccine, antibody, protein, polypeptide, antigen-presenting cell or immune effector cell.

La présente invention concerne l'utilisation de gènes différemment exprimés dans des cellules cibles pour mettre au point des vaccins afin de générer une réponse immunitaire. La méthode selon l'invention concerne des compositions et méthodes destinées à induire une réponse immunitaire contre des cellules gp100 de mélanome et contre des cellules HER-2?+¿. L'invention concerne également des méthodes de traitement et de prévention, par des vaccins contre le cancer et par immunothérapie adoptive, de troubles associés à la présence de ces cellules chez un sujet. On peut appliquer les méthodes selon l'invention en administrant au sujet le gène ou vaccin contre le cancer, l'anticorps, la protéine, le polypeptide, la cellule présentatrice de l'antigène ou la cellule effectrice immunitaire approprié.

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