Genes encoding abc1 paralogs and the polypeptides derived...

Details Genes encoding abc1 paralogs and the polypeptides derived... Genes encoding abc1 paralogs and the polypeptides derived...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 48/00 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2397324

The present invention relates to three novel genes and polypeptides derived therefrom encoding "PD-ABC" proteins. The invention also describes methods for using the novel gene and polypeptides in the detection of genetic deletions of the gene, subcellular localization of the polypeptide, binding assays in connection with the chemical databases, gene therapy, and identification of chemicals which may be used in the therapeutic treatment of PD-ABC-mediated diseases.

L'invention concerne trois nouveaux gènes et des polypeptides dérivés de ceux-ci, qui codent pour des protéines de <= PD-ABC >=. L'invention concerne également des procédés d'utilisation du nouveau gène et des polypeptides pour détecter des délétions génétiques du gène, à des fins de localisation sous-cellulaire du polypeptide, dans des techniques de titrage par liaison associées à des bases de données chimiques, en thérapie génique et pour identifier des produits chimiques pouvant être utilisés dans le traitement thérapeutique de maladies dépendant de PD-ABC.

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