Genes encoding branched-chain alpha-ketoacid dehydrogenase...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/53 (2006.01) C12N 1/21 (2006.01) C12N 9/02 (2006.01) C12N 15/70 (2006.01) C12P 19/62 (2006.01)

Patent

CA 2167520

The present invention relates to DNA sequences that encode for the branched-chain alpha-ketoacid dehydrogenase complex of an organism belonging to the genus Streptomyces and to polypeptidesproduced by the expression of such sequences. It also relates to methods of enhancing the production of natural avermectin and of producing avermectin through fermentation.

Séquences d'ADN codant pour le complexe déshydrogénase cétoacide-alpha à chaîne ramifiée d'un organisme du genre Streptomyces, et polypeptides produits par l'expression de ces séquences. L'invention concerne également des procédés d'amélioration de la production d'avermectine naturelle et de production de l'avermectine par fermentation.

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