C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 15/63 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2341155
The present invention relates to a novel DNA sequence that codes for expression of a human Death Inducer-Obliterator 1 (DIO-1)gene and the polypeptide derived from the DNA sequence. Expression vectors containing such sequences and host cells transformed with such expression vectors are also disclosed, as are methods for the expression of the novel DIO-1 polypeptide of the invention, and uses thereof.
La présente invention se rapporte à une nouvelle séquence d'ADN qui code pour l'expression d'un gène humain annulateur-inducteur de mort cellulaire 1 (DIO-1 Death Inducer-Obliterator 1), ainsi qu'au polypeptide dérivé de ladite séquence d'ADN. L'invention se rapporte également à des vecteurs d'expression contenant de telles séquences et à des cellules hôtes transformées par de tels vecteurs d'expression. L'invention se rapporte enfin à des méthodes d'expression du nouveau polypeptide DIO-1 et à des utilisations de ce dernier.
Alonso Carlos Martinez
Domingo David Garcia
Grandien Alf
Leonardo Esther
Martinez Pedro
Consejo Superior de Investigaciones Cientificas
Hill & Schumacher
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