Genes expressed in breast cancer as prognostic and...

Details Genes expressed in breast cancer as prognostic and... Genes expressed in breast cancer as prognostic and...

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C12N 15/86 (2006.01) C12N 15/861 (2006.01)

Patent

CA 2443627

Methods are disclosed for, determining the endocrine responsiveness of breast carcinoma and treating and monitoring the progression of breast carcinoma based on genes which are differentially expressed in breast tumors. Also disclosed are methods for identifying agents useful in the treatment of breast carcinoma, methods for monitoring the efficacy of a treatment for breast carcinoma, methods for inhibiting the proliferation of a breast carcinoma, and breast,specific vectors including the promoters of the disclosed genes.

L'invention concerne des procédés destinés à déterminer la réceptivité endocrine du carcinome mammaire et à traiter et à suivre la progression du carcinome mammaire en fonction des gènes qui sont exprimés différentiellement dans les tumeurs mammaires. Elle concerne aussi des procédés d'identification d'agents utiles dans le traitement du carcinome mammaire, des procédés de suivi de l'efficacité d'un traitement du carcinome mammaire, de procédés d'inhibition de la prolifération d'un carcinome mammaire, ainsi que des vecteurs mammaires spécifiques comprenant les promoteurs des gènes concernés.

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