Genes for the biosynthesis of epothilones

Details Genes for the biosynthesis of epothilones Genes for the biosynthesis of epothilones

C - Chemistry, Metallurgy

12

N

C12N 15/52 (2006.01) C07D 493/00 (2006.01) C07K 14/195 (2006.01) C07K 14/535 (2006.01) C12P 17/18 (2006.01)

Patent

CA 2329774

Nucleic acid molecules are isolated from Sorangium cellulosum that encode polypeptides necessary for the biosynthesis of epothilone. Disclosed are methods for the production of epothilone in recombinant hosts transformed with the genes of the invention. In this manner, epothilone can be produced in quantities large enough to enable their purification and use in pharmaceutical formulations such as those for the treatment of cancer.

L'invention porte: sur des molécules d'acide nucléique isolées à partir de Sorangium cellulosum et codant pour des polypeptides nécessaires à la biosynthèse de l'épothilone; sur des procédés de production d'épothilone dans des hôtes de recombinaison transformés au moyen des gènes de l'invention. On peut ainsi produire l'épothilone en quantités suffisantes pour permettre sa purification et son utilisation dans des préparation pharmaceutiques telles que celles utilisées pour le traitement du cancer.

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