Genes identified as required for proliferation of e. coli

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/31 (2006.01) C07K 14/245 (2006.01) C12N 15/10 (2006.01) C12N 15/11 (2006.01)

Patent

CA 2395335

The sequences of nucleic acids encoding proteins required for E. coli proliferation are disclosed. The nucleic acids can also be used to screen for homologous genes that are required for proliferation in microorganisms other than E. coli. The nucleic acids can also be used to design expression vectors and secretion vectors. The nucleic acids can be used to express proteins or portions thereof, to obtain antibodies capable of specifically binding to the expressed proteins, and to use those expressed proteins as a screen to isolate candidate molecules for rational drug discovery programs. The nucleic acids of the present invention can also be used in various assay systems to screen for antimicrobial agents.

L'invention concerne les séquences d'acides nucléiques codant des protéines requises pour la prolifération de E. coli. Les acides nucléiques peuvent aussi être utilisés pour cribler des gènes homologues requis pour la prolifération dans des micro-organismes autres que E. coli. Les acides nucléiques peuvent aussi être utilisés pour concevoir des vecteurs d'expression ainsi que des vecteurs de sécrétion. Les acides nucléiques peuvent être utilisés pour exprimer des protéines ou des parties de celles-ci, afin d'obtenir des anticorps capables de se fixer spécifiquement aux protéines exprimées, et pour utiliser ces protéines exprimées en tant que crible pour isoler des molécules potentielles destinées à des programmes de découverte de médicaments rationnels. Les acides nucléiques de la présente invention peuvent également être utilisés dans divers systèmes de dosage pour cribler des agents anti-microbiens.

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