Genes involved in immune related responses observed with asthma

Details Genes involved in immune related responses observed with asthma Genes involved in immune related responses observed with asthma

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2419725

Asthma is one of the most common chronic diseases (155 million people worldwide) and is rapidly increasing (20-50 % per decade), particularly in children (currently 10 % in The Netherlands). Asthma impairs the quality of life and is a major cause of absence from school and work. Asthma, if not treated properly, can be life threatening. The invention provides a nucleic acid library comprising genes or functional fragments thereof said genes are essentially capable of initiation and/or progression and/or suppression and/or repression of an immune response.

L'asthme est l'une des maladies chroniques les plus fréquentes (155 millions d'individus souffrant d'asthme dans le monde), qui augmente très rapidement (20 à 50 % par décennie) en particulier chez les enfants (actuellement 10 % aux Pays-Bas). L'asthme dégrade la qualité de vie et constitue une des principales causes d'absentéisme au travail et à l'école. En l'absence de traitement correct, l'asthme peut être mortel. L'invention concerne une bibliothèque d'acides nucléiques comprenant des gènes ou des fragments fonctionnels desdits gènes. Ces gènes sont essentiellement capables d'initier et/ou faire progresser et/ou supprimer et/ou réprimer la réponse immunitaire.

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