C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2340465
The present invention provides an isolated nucleic acid derived from an isolated hematopoietic stem cell. The present invention additionally provides an isolated hematopoietic stem cell specific protein or a portion thereof encoded by the provided nucleic acid. In addition, the present invention provides a method for generating a stem cell/progenitor cell from a primitive hematopoietic cell. Also, the present invention further provides a method for identifying the presence in a sample of a compound that modulates hematopoietic stem cell activity. The present invention additionally provides a molecularly defined primitive hematopoietic stem cell. Finally, the present invention provides a method of ex vivo expansion of hematopoietic stem cells.
L'invention concerne un acide nucléique isolé dérivé d'une cellule souche hématopoïétique isolée. Elle concerne également une protéine spécifique de cellule souche hématopoïétique ou une portion de cette protéine codée par l'acide nucléique décrit. L'invention concerne en outre un procédé permettant de produire une cellule souche/cellule précurseur d'une cellule hématopoïétique primitive, ainsi qu'un procédé permettant d'identifier la présence d'un composant modulant l'activité des cellules souches hématopoïétiques dans un échantillon. De plus, L'invention concerne une cellule souche hématopoïétique primitive dont la composition moléculaire a été définie. Enfin L'invention concerne un procédé de culture ex vivo de cellules souches hématopoïétiques.
Lemischka Ihor
Moore Kateri
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Princeton University
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