C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/18 (2006.01) A01K 67/027 (2006.01) A61K 38/17 (2006.01) C07K 14/475 (2006.01) C07K 16/18 (2006.01) C12N 5/10 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2309383
The invention relates to the field of neurology, psychiatry, neuropathology and neuropharmacology, more specifically to neurological and psychiatric disorders such as Parkinson's disease and tardive dyskinesia, and psychiatric disorders such as schizophrenia, addiction and affective disorders, like manic depression, and other disorders related to malfunctioning of the mesencephalic dopaminergic (mesDA) system. The invention provides an isolated and/or recombinant nucleic acid or a specific fragment, homologue or derivative thereof, corresponding to a gene with restricted expression in mesencephalic dopaminergic neurons, wherein said gene is related to neurological and psychiatric disorders such as Parkinson's disease, tardive dyskinesia, manic depression and schizophrenia.
L'invention se rapporte aux domaines neurologique, psychiatrique, neuropathologique et neuropharmacologique, et tout particulièrement aux troubles neurologiques et psychiatriques tels que la maladie de Parkinson et la dyskinésie tardive, et aux troubles psychiatriques tels que la schizophrénie, la toxicomanie et les troubles affectifs, du type maladie affective bipolaire, et autres troubles associés au dysfonctionnement du système mésencéphalique dopaminergique (mesDA). L'invention se rapporte à un acide nucléique isolé et/ou recombiné ou à un fragment spécifique, homologue ou dérivé de cet acide nucléique, correspondant à un gène ayant une expression réduite dans les neurones mésencéphaliques dopaminergiques. Le gène en question est lié aux troubles neurologiques et psychiatriques du type maladie de Parkinson, dyskinésie tardive, maladie affective bipolaire et schizophrénie.
Burbach Johannes Peter Henri
Smidt Marten Piet
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